![]() I wanted what I thought everyone got: happy, smiling, healthy, safe, chubby, cute, little bundles of joy. I hadn't signed up for this: a sick baby. Had I done something wrong? Was she going to be OK? Could she be disabled? Could she die? And, selfishly, I felt angry, even resentment towards her. More and more bricks of fear and self-doubt stacked themselves on my shoulders. Something that I might not be able to fix. But now I had the added fear that there was something wrong with her to contend with. Not to mention once I had the baby I was going to be expected to not totally screw her up. I was growing a tiny human inside of me, from a small collection of cells to what would one day become a completely autonomous being. Pregnancy is both an incredible and terrifying experience. And bad things don't happen to good people, so of course we'd be fine - and our baby would, too. ![]() My partner and I told each other that we were healthy, we were happy, and most importantly, we were good people. We'd consulted Google – normally a horrible idea – and decided that swollen ventricles, while scary, often had a safe and healthy outcome. Long before we knew exactly what was waiting for us at the end of that 28-week visit, my partner and I drove to the hospital, I felt nervous but confident. If I was already worried about parenting, how could I parent a child when something was wrong? I felt angry, even resentment towards her. My 28-week ultrasound confirmed my worst nightmare and it threw everything into complete chaos. But that ultrasound effectively ruined the vision I had created for myself of a happy, healthy pregnancy producing a happy, healthy baby. After three weeks of diagnostic Level 2 ultrasounds, blood tests, and MRIs and three weeks of doctors speculating about possible viral infections, hydrocephalus, and shunts, we were finally going to get some answers. This type of inflammation, known as ventriculomegaly, is associated with a number of developmental disorders. At 28 weeks gestation, her lateral ventricles were double normal size (these are important because they carry cerebral spinal fluid to her spinal cord). Three weeks earlier, a sonographer had seen an abnormality in my unborn daughter’s brain. This methodology will provide a means to evaluate respiratory therapies with respect to airway mechanics.I just want my baby to be OK, I repeated over and over again on a Thursday morning last April. Temporal changes in bulk and Young's moduli demonstrate the time dependence of alterations in conducting airway mechanical properties in vivo during the course of mechanical ventilation. US measurements are used to normalize pressure-volume data for resting volume, calculation of bulk modulus, stress-strain relationships and the adapted Young's modulus associated with tangential wall stress. US dimensional measurements of the segments are made while static (no distending pressure) and at pressure limits during dynamic ventilator cycling. Serially, tracheal segments are filled with saline and pressure-volume relationships are recorded with stepwise volume infusions. In this protocol, tracheal segments are isolated in a spontaneously breathing newborn lamb model and the segments are exposed to time-cycled, pressure-limited mechanical ventilation. In this report we introduce an adaptation of engineering concepts using US imaging data to study airway mechanics in vivo. Advances in ultrasound (US) technology allow for real-time imaging and accurate measurement of tracheal dimensions in vivo thus, changes in mechanical properties can be tracked longitudinally. Alterations in neonatal airway mechanical properties resulting from ventilatory therapies such as mechanical ventilation have been implicated in airway collapse and chronic disease.
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